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Per amore delle rondini

Il Cambiamento - feed -

Non siamo più capaci di amare la vita e di difenderla e preservarla. La vita: i nostri figli, tutti i bambini, i boschi, i prati, gli altri animali, l'acqua e la terra. In una società in cui tutto è competizione, la confusione e la cecità regnano sovrane, e il profitto e la scalata sociale, con l'ostentazione che ne consegue, sono i primi valori.

Trends of and factors associated with cesarean section related surgical site infections in Guinea

Medici Senza Frontiere - feed -

Trends of and factors associated with cesarean section related surgical site infections in Guinea Delamou, A; Camara, BS; Sidibe, S; Camara, A; Dioubate, N; Ayadi, AME; Tayler-Smith, K; Beavogui, AH; Balde, MD; Zachariah, R Since the adoption of free obstetric care policy in Guinea in 2011, no study has examined the surgical site infections in maternity facilities. The objective of this study was to assess the trends of and factors associated with surgical site infection following cesarean section in Guinean maternity facilities from 2013 to 2015. This was a retrospective cohort study using routine medical data from ten facilities. Overall, the incidence of surgical site infections following cesarean section showed a declining trend across the three periods (10% in 2013, 7% in 2014 and 5% in 2015, P<0.001). Women who underwent cesarean section in 2014 (AOR: 0.70; 95%CI: 0.57-0.84) and 2015 (AOR: 0.43; 95%CI: 0.34-0.55) were less likely to develop surgical site infections during hospital stay than women operated in 2013. In the contrary, women with comorbidities were more likely to experience surgical site infection (AOR: 1.54; 95% CI: 1.25-1.90) than those who did not have comorbidities. The reductions achieved in 2014 and 2015 (during the Ebola outbreak) should be sustained in the post-Ebola context.

Venezuela: UN human rights office calls for ‘maximum restraint’ by authorities in face of new demonstrations

ONU - aiuti umanitari - feed -

With another day of mass protests taking place across Venezuela, the UN human rights office (OHCHR) said on Wednesday it was “extremely worried by reports of the excessive use of force” by security forces, loyal to President Nicolás Maduro, a day after an opposition-led uprising appeared to stall. 

Bedaquiline and delamanid in combination for treatment of drug-resistant tuberculosis

Medici Senza Frontiere - feed -

Bedaquiline and delamanid in combination for treatment of drug-resistant tuberculosis Mohr, E; Ferlazzo, G; Hewison, C; De Azevedo, V; Isaakidis, P Here we report on the final outcomes for the cohort of 28 patients from Armenia, India, and South Africa who initiated regimens containing the combination of bedaquiline and delamanid from January to August, 2016, for the treatment of multidrug-resistant tuberculosis in our cohort study.1 The median duration on combination treatment was 12 months (interquartile range [IQR] 5·9–20·0); 17 (61%) of 28 patients received the combination for more than 6 months.

Maledetti Toscani, viaggio tra pellami e sapori di qualità

BuoneNotizie.it -

Maledettamente bravi, maledettamente creativi e comunicativi. Simpatici “a pelle” visto che è proprio la pelle che scelgono, lavorano, producono nei diversi settori dell’abbigliamento, ad essere la ragione della loro vita imprenditoriale e forse di vita. Maledetti Toscani: un binomio, una storia, una imprenditoria e un futuro tutto da raccontare. 

Alessandro e Nicola Quadri: così diversi ma così maledettamente simili quando mettono in campo la loro creatività.  Passandosi il testimone l’uno con l’altro con un solo obiettivo: tagliare di volta in volta il traguardo della genialità. Vengono da lontano i Quadri: una storia che ha inizio nel 1848. Alessandro, detto il “Belli”. Segno zodiacale leone. Orgoglioso, tenace, maniacale per il “tutto e sempre made in Italy” ed ossessivo quando si tratta “del rispetto per il cliente, sempre e comunque”. Trequartista da piccolo quando giocava a calcio adesso si è spostato nel ruolo che più lo compete “il regista dell’Azienda”. L’altra metà del cielo, come il nostro Belli ama definirlo, è “Nikke”, al secolo Nicola: meticoloso, preciso, perfezionista, attento ai dettagli ma soprattutto maniacalmente creativo. Segno zodiacale: manco a dirlo, Vergine. Subito sembra “il bel tenebroso”, poi diventa sorgnone. Ma quando entra in sintonia piazza i colpi migliori: perché è maledettamente artista, a tutto campo. E’ creativo il Nikke: disegna a mano, costruisce a mano, taglia la pelle conciata a mano; e tutti i negozi MT in Italia e nel mondo sono usciti dalla sua testa.

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L'articolo Maledetti Toscani, viaggio tra pellami e sapori di qualità è tratto da BuoneNotizie.it.

Diagnostic value of the urine lipoarabinomannan assay in HIV-positive, ambulatory patients with CD4 below 200 cells/μl in 2 low-resource settings: A prospective observational study.

Medici Senza Frontiere - feed -

Diagnostic value of the urine lipoarabinomannan assay in HIV-positive, ambulatory patients with CD4 below 200 cells/μl in 2 low-resource settings: A prospective observational study. Huerga, H; Mathabire Rucker, SC; Cossa, L; Bastard, M; Amoros, I; Manhica, I; Mbendera, K; Telnov, A; Szumilin, E; Sanchez-Padilla, E; Molfino, L BACKGROUND: Current guidelines recommend the use of the lateral flow urine lipoarabinomannan assay (LAM) in HIV-positive, ambulatory patients with signs and symptoms of tuberculosis (TB) only if they are seriously ill or have CD4 count ≤ 100 cells/μl. We assessed the diagnostic yield of including LAM in TB diagnostic algorithms in HIV-positive, ambulatory patients with CD4 < 200 cells/μl, as well as the risk of mortality in LAM-positive patients who were not diagnosed using other diagnostic tools and not treated for TB. METHODS AND FINDINGS: We conducted a prospective observational study including HIV-positive adult patients with signs and symptoms of TB and CD4 < 200 cells/μl attending 6 health facilities in Malawi and Mozambique. Patients were included consecutively from 18 September 2015 to 27 October 2016 in Malawi and from 3 December 2014 to 22 August 2016 in Mozambique. All patients had a clinical exam and LAM, chest X-ray, sputum microscopy, and Xpert MTB/RIF assay (Xpert) requested. Culture in sputum was done for a subset of patients. The diagnostic yield was defined as the proportion of patients with a positive assay result among those with laboratory-confirmed TB. For the 456 patients included in the study, the median age was 36 years (IQR 31-43) and the median CD4 count was 50 cells/μl (IQR 21-108). Forty-five percent (205/456) of the patients had laboratory-confirmed TB. The diagnostic yields of LAM, microscopy, and Xpert were 82.4% (169/205), 33.7% (69/205), and 40.0% (84/205), respectively. In total, 50.2% (103/205) of the patients with laboratory-confirmed TB were diagnosed only through LAM. Overall, the use of LAM in diagnostic algorithms increased the yield of algorithms with microscopy and with Xpert by 38.0% (78/205) and 34.6% (71/205), respectively, and, specifically among patients with CD4 100-199 cells/μl, by 27.5% (14/51) and 29.4% (15/51), respectively. LAM-positive patients not diagnosed through other tools and not treated for TB had a significantly higher risk of mortality than LAM-positive patients who received treatment (adjusted risk ratio 2.57, 95% CI 1.27-5.19, p = 0.009). Although the TB diagnostic conditions in the study sites were similar to those in other resource-limited settings, the added value of LAM may depend on the availability of microscopy or Xpert results. CONCLUSIONS: LAM has diagnostic value for identifying TB in HIV-positive patients with signs and symptoms of TB and advanced immunodeficiency, including those with a CD4 count of 100-199 cells/μl. In this study, the use of LAM enabled the diagnosis of TB in half of the patients with confirmed TB disease; without LAM, these patients would have been missed. The rapid identification and treatment of TB enabled by LAM may decrease overall mortality risk for these patients.

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